Drug Name Anafranil

Mechanism of action. Na+-channel blocking antiarrhythmics resemble most local anesthetics in being cationic amphiphilic molecules (exception: phenytoin). Possible molecular mechanisms of their inhibitory effects are outlined in more detail. Their low structural specificity is reflected by a low selectivity towards different cation channels.
The enteric musculature reacts with increased peristalsis. The aims of antidiarrheal therapy are to prevent: (1) dehydration and electrolyte depletion; and (2) excessively high stool frequency. Different therapeutic approaches (in green) listed are variously suited for these purposes. Adsorbent powders are nonabsorbable materials with a large surface area.

 

The effect of T3 develops more rapidly and has a shorter duration than does that of T4. Plasma elimination t1/2 for T4 is about 7 d; that for T3, however, is only 1. 5 d. Conversion of T4 to T3 releases iodide; 150 ?g T4 contains 100 ?g of iodine. For therapeutic purposes, T4 is chosen, although T3 is the active form and better absorbed from the gut.
Abrupt termination of continuous treatment can be followed by rebound hypertension (particularly with short t1/2 ?-blockers). Drugs for the control of hypertensive crises include nifedipine (capsule, to be chewed and swallowed), nitroglycerin (sublingually), clonidine (p. o. or i. v. , p. 96), dihydralazine (i. v. ), diazoxide (i. v. ), fenoldopam (by infusion) and sodium nitroprusside.