Drug Name Aldactone

Consequently, less fluid is absorbed than is secreted. The increased filling of the bowel promotes peristalsis; excitation of sensory nerve endings elicits enteral hypermotility. According to the site of irritation, one distinguishes the small bowel irritant castor oil from the large bowel irritants anthraquinone and diphenolmethane derivatives (for details see p. 174).
The most common unwanted effect is gastrointestinal upset (nausea, vomiting, diarrhea, etc. ) due to (1) a direct mucosal irritant action of these substances and (2) damage to the natural bacterial gut flora (broad-spectrum antibiotics) allowing colonization by pathogenic organisms, including Candida fungi.

 

In addition, a drug may also cause unwanted effects that can be grouped into minor or “side” effects and major or adverse effects. These, in turn, may give rise to complaints or illness, or may even cause death. Causes of adverse effects: overdosage (A). The drug is administered in a higher dose than is required for the principal effect; this directly or indirectly affects other body functions.
Disorders of extrapyramidal motor function with development of pseudo-Parkinsonism, sedation, depression, stuffy nose, impaired libido, and impotence; increased appetite. These adverse effects have rendered the drug practically obsolete. Guanethidine possesses high affinity for the axolemmal and vesicular amine transporters.