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Matching dosage of the oral antidiabetic and caloric intake follows the same principles as apply to insulin. Hypoglycemia is the most important unwanted effect. Enhancement of the hypoglycemic effect can result from drug interactions: displacement of antidiabetic drug from plasma protein-binding sites by sulfonamides or acetylsalicylic acid.
Centrally acting muscle relaxants (A) lower muscle tone by augmenting the activity of intraspinal inhibitory interneurons. They are used in the treatment of painful muscle spasms, e. g. , in spinal disorders. Benzodiazepines enhance the effectiveness of the inhibitory transmitter GABA (p. 226) at GABAA receptors. Baclofen stimulates GABAB receptors.

 

Bisphosphonates irritate esophageal and gastric mucus membranes; tablets should be swallowed with a reasonable amount of water (250 mL) and the patient should keep in an upright position for 30 min following drug intake.
This, in turn, elicits a secretion of epinephrine (= adrenaline) into the blood, by which it is distributed to body tissues as a hormone (A). Adrenergic Synapse Within the varicosities, norepinephrine is stored in small membrane-enclosed vesicles (granules, 0. 05 to 0. 2 ?m in diameter).

 

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