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Therefore, the thyroid increases in size. In addition, intrathyroid depletion of iodine stimulates growth. Because of the negative feedback regulation of thyroid function, thyroid activation can be inhibited by administration of T4 doses equivalent to the endogenous daily output (approx. 150 ?g/d). Deprived of stimulation, the inactive thyroid regresses in size.
Ethinylestradiol (EE) is more stable metabolically, passes largely unchanged through the liver after oral intake and mimics estradiol at estrogen receptors. Mestranol itself is inactive; however, cleavage of the C-3 methoxy group again yields EE. In oral contraceptives, one of the two agents forms the estrogen component.

 

Skin Protection (A) Protective agents are of several kinds to meet different requirements according to skin condition (dry, low in oil, chapped vs moist, oily, elastic), and the type of noxious stimuli (prolonged exposure to water, regular use of alcoholcontaining disinfectants, intense solar irradiation).
The chemically simple molecule is now produced synthetically. Erythromycin suppresses advancement of the ribosome. Its action is predominantly bacteriostatic and directed against gram-positve organisms. For oral administration, the acid-labile base (E) is dispensed as a salt (E. stearate) or an ester (e. g. , E. succinate). Erythromycin is well tolerated.

 

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